New drug prompts stem cells to grow into hair-like cilia cells – Daily Mail
A gel that’s injected into the ear could reverse hearing loss. Called FX-322, the one-off jab works by encouraging dormant stem cells inside the ear to grow into healthy new auditory cells capable of transmitting sounds to the brain.
Stem cells are immature cells found throughout the body, and many have the capacity to grow into virtually any type of tissue.
The new drug prompts these dormant cells …….
A gel that’s injected into the ear could reverse hearing loss. Called FX-322, the one-off jab works by encouraging dormant stem cells inside the ear to grow into healthy new auditory cells capable of transmitting sounds to the brain.
Stem cells are immature cells found throughout the body, and many have the capacity to grow into virtually any type of tissue.
The new drug prompts these dormant cells to grow into cilia. These tiny hair-like cells pick up sounds and turn them into electrical impulses that are sent along the auditory nerve to the brain for processing.
Around 11 million people in the UK are affected by hearing loss, eight million of whom are aged 60 or older. Short-term hearing loss can occur as a result of ear infections or wax build-up.
Stem cells are immature cells found throughout the body, and many have the capacity to grow into virtually any type of tissue. The new drug prompts these dormant cells to grow into cilia
But while this is treatable, hearing loss due to damage to the cilia — for example, from repeated exposure to loud noise or changes in the inner ear as we age — is largely untreatable because the cells cannot repair themselves.
Hearing loss is also linked with tinnitus (constant ringing or buzzing noise in the ears) and with an increased risk of dementia, possibly because the brain has to direct more energy towards understanding speech.
Hearing aids can help by amplifying sound, but the hope is that the new drug could do away with the need for them by restoring healthy hearing. Developed by Frequency Therapeutics, a company linked to the Massachusetts Institute of Technology in the U.S., the gel contains a mixture of drugs that, in laboratory tests, helped new hair cells form from a type of stem cell called progenitor cells.
One of the drugs included is valproic acid, a readily available and relatively cheap drug already used as an anti-convulsant for epilepsy. Unlike other types of stem cell, progenitor cells cannot develop into any form of body tissue. Instead they are more likely to develop into cells near where they are found in the body.
Called FX-322, the one-off jab works by encouraging dormant stem cells inside the ear to grow into healthy new auditory cells capable of transmitting sounds to the brain
Those in the inner ear, for example, are most likely to develop into cells typically found nearby — such as the tiny hearing cells. Animal studies have found the gel increases the number of healthy hair cells.
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